Correlation of immunostaining findings with demographic data and variables of Oxford classification in IgA nephropathy.

IgG deposition in IgA nephropathy patients

IgA nephropathy is the most common form of glomerular disease among young adults. The aim of this study is to determine the correlation of IgG deposition with morphologic variables of Oxford classification and some clinical data of patients with IgA nephropathy (IgAN).A total of 114 biopsies were enrolled to the study (70.2% were male). Mean age of the patients was 37.7±13.6 years. This study s...

IgA Nephropathy and Significance of Immunostaining Data

Immunostaining findings in IgA nephropathy: correlation with histology and clinical outcome in the Oxford classification patient cohort.

BACKGROUND IgA nephropathy is defined by the presence of IgA-dominant glomerular deposits. Within this definition, there is variation in the location of IgA and the presence of other immunoglobulins. The Oxford classification of IgA nephropathy identifies four histological features that are independent predictors of clinical outcome but does not include immunostains. Here, we investigate the po...

R: IgG deposition in IgA nephropathy patients

Dear Editor-in-Chief, I read with great interest the recently published article by Nasri H. entitled “IgG deposition in IgA nephropathy patients” in the esteemed Journal of Renal Injury Prevention. In this study on 114 biopsies of IgA nephropathy (IgAN) patients they found no significant association of IgG deposits with age. There was no correlation of IgG deposit with four morphologic variable...

Comment on: Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients

Implication for health policy/practice/research/medical education: It is essential to conduct more studies using a larger number of patients or studies from different geographic parts and ethnicities to obtain the other important prognostic morphologic variables, other than four morphologic variables of Oxford classification. Commentary Please cite this paper as: Baradaran A. Comment on: Associ...